Select Publications

  • *Kitt, M.M., *Tabuchi, N., Spencer, W.C., Robinson, H., Zhang, X.L., Eastman, B. A., Lobur, K.J., Silver, J., Mei, L., Deneris, E.S. (2022) An adult-stage transcriptional program for survival of serotonergic connectivity.  Cell Reports 2022 Apr 19;39(3) PMID: 35443166; PMCID: PMC9109281. doi: 10.1016/j.celrep.2022.110711.

  • *Zhang, X, *Spencer, WC, Tabuchi, N, Kitt, MM, Deneris, ES (2022) Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity, eLife 2022 Apr 26; PMCID: PMC9098219. DOI: 10.7554/eLife.75970

  • Donovan, LJ, Spencer WC, Kitt MM, Eastman BA, Lobur KJ, Jiao K, Silver J, Deneris ES. (2019) Lmx1b is required at multiple stages to build expansive serotonergic axon architectures. eLife Jul 29;8. pii: e48788. PMCID: PMC6685705 DOI: 10.7554/eLife.48788

  • Deneris, E. and Gaspar, P. (2017) Serotonin neuron development: shaping molecular and structural identities. Wiley Interdiscip Rev Dev Biol. Jan;7(1). doi: 10.1002/wdev.301. Epub 2017 Oct 26. PMCID: PMC5746461.

  • Spencer, W C. and Deneris, E. (2017) Regulatory mechanisms controlling maturation of serotonin neuron identity and function. Front Cell Neurosci. Jul 19;11:215. doi: 10.3389/fncel.2017.00215. PMID 28769770 PMCID: PMC5515867

  • Whitney MS, Shemery AM, Yaw AM, Donovan LJ, Glass JD, Deneris ES. (2016) Adult brain serotonin deficiency causes hyperactivity, circadian disruption, and elimination of siestas. Journal of Neuroscience 36:9828-9842. Featured: This week in the Journal.  Selected as Journal Clubs article February 15, 2017 37(7). PMCID: PMC5030349 DOI: 10.1523/JNEUROSCI.1469-16.2016

  • Wyler SC*, Spencer WC*, Green NH, Rood BD, Crawford L, Craige C, Gresch P, McMahon DG, Beck SG, Deneris E. (2016) Pet-1 switches transcriptional targets postnatally to regulate maturation of serotonin neuron excitability. Journal of Neuroscience 36:1758-74. PMCID: PMC4737783 DOI: 10.1523/JNEUROSCI.1469-16.2016

  • Deneris, E. and Hobert, O. (2014) Maintenance of postmitotic neuronal cell identity Nature Neuroscience. 17:899-907. . PMCID: PMC4472461 DOI: 10.1038/nn.3731.

  • Deneris ES, Wyler SC. (2012) Serotonergic transcriptional networks and potential importance in mental health Nature Neuroscience 15:519-27 PMCID: PMC3594782 DOI: 10.1038/nn.3039.

  • Fox, S.R. and Deneris, E.S. (2012)
    Engrailed is required in maturing serotonin neurons to regulate the cytoarchitecture and survival of the dorsal raphe nucleus. Journal of Neuroscience. 32:7832-7842. PMCID: PMC3521159. doi: 10.1523/JNEUROSCI.5829-11.2012.

  • Liu, C., Maejima, T., Wyler, S., Casadesus, G., Herlitze, Deneris, E.S. (2010)
    Pet-1 is Required Across Different Stages of Life to Regulate Serotonergic Function. Nature Neuroscience. 13:1190-1198 PMCID: PMC2947586. DOI: 10.1038/nn.3731.

  • Wylie, C.J., Hendricks, T.J., Zhang, B., Wang, L., Lu, P., Leahy, P., Fox, S., Maeno, H., and Deneris, E.S. (2010)
    Distinct transcriptomes define rostral and caudal serotonin neurons Journal of Neuroscience 30:670-684. PMCID: PMC3403750 DOI: 10.1523/JNEUROSCI.4656-09.2010

  • Krueger, K.C. and Deneris, E.S. (2008)
    Serotonergic transcription of human FEV reveals direct GATA factor interactions and fate of Pet-1 deficient serotonin neuron precursors. Journal of Neuroscience 28:12748-12758 PMCID: PMC2610260. doi: 10.1523/JNEUROSCI.4349-08.2008.

  • Lerch-Haner, J.K., Frierson, D., Crawford, L., Beck, S. and Deneris, E.S. (2008)
    Serotonergic transcriptional programming determines maternal behavior and offspring survival. Nature Neuroscience 11:1001-1003 PMCID: PMC2679641. DOI: 10.1038/nn.2176. Nature Research Highlights, August 2008.

  • Erickson, J.T., Shafer, G., Rossetti, M.D., Wilson, C. G., and Deneris, E.S. (2007)
    Arrest of 5HT neuron differentiation delays respiratory maturation and impairs neonatal homeostatic responses to environmental challenges Respir. Physiol. Neurobiol. 159:85-101 PMCID: PMC2593840. DOI: 10.1016/j.resp.2007.06.002.

  • *Zhao, Z. Q., *Scott, M.M., Chiechio, S., Wang, J.S., Renner, K.J., Gereau, R.W. IV Johnson, R.L., Deneris, E.S., and Chen, Z.F. (2006)
    Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotive activity. Journal of Neuroscience 26:12781-12788. PMCID: PMC6674835. doi: 10.1523/JNEUROSCI.4143-06.2006.

  • Xu, X, Scott, M.M. and Deneris, E. (2006)
    Shared long-range regulatory elements coordinate expression of a gene cluster encoding nicotinic receptor heteromeric subtypes Molecular and Cellular Biology 26:5636-5649. PMCID: PMC1592759. doi: 10.1128/MCB.00456-06. 

  • Scott, M.S., Wylie, C.W., Lerch, J.K., Murphy, R., Lobur, K., Herlitze, S., Jiang, W., Conlon, R.A., Strowbridge, B., and Deneris, E.S. (2005)
    A genetic approach to access serotonin neurons for in vivo and in vitro studies. PNAS. 2005 Nov 8; 102(45):16472-16477. PMCID: PMC1283423 DOI: 10.1073/pnas.0504510102.

  • Scott MM, Krueger KC, Deneris ES. (2005)
    A differentially autoregulated Pet-1 enhancer region is a critical target of the transcriptional cascade that governs serotonin neuron development. Journal of Neuroscience 2005 Mar 9; 25(10):2628-2636. PMC6725185. doi: 10.1523/JNEUROSCI.4979-04.2005.

  • Hendricks TJ, Fyodorov DV, Wegman LJ, Lelutiu NB, Pehek EA, Yamamoto B, Silver J, Weeber EJ, Sweatt JD, Deneris ES. (2003)
    Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron. 2003 Jan 23; 37(2):233-247. PMID: 12546819 DOI: 10.1016/s0896-6273(02)01167-4 Featured article for the January 23rd issue of Neuron

  • Hendricks T, Francis N, Fyodorov D, Deneris ES. (1999)
    The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. Journal of Neuroscience 1999 Dec 1; 19(23):10348-10356. PMCID: PMC6782418. DOI: 10.1523/JNEUROSCI.19-23-10348.1999.

  • Deneris, E.S., Connolly, J., Boulter, J., Wada, E., Wada, K., Swanson, L., Patrick, J., and Heinemann, S. (1988) Primary structure and expression of beta2: a novel subunit of neuronal nicotinic acetylcholine receptors. Neuron 1: 45-54. doi: 10.1016/0896-6273(88)90208-5. PMID: 3272154.